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Discussion Understanding how nicotine affects decision-making has been challenging, because two different physiological aspects need to be distinguished 41 : (i) nicotine as a reinforcer that directly activates the dopaminergic system to produce reinforcement and nicotine-seeking, and (ii) nicotine as a neuromodulator that alters nicotine-independent decision-making processes by modifying the dynamics and computational properties of cholinoceptive circuits

Postural drainage allows the force of gravity to assist in the removal of bronchial secretions by assuming several positions, which can contribute to effective drainage of a different lobe of the lungs