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Consequently, the targeted inhibition of GOT1, in conjunction with its upstream and downstream pathways, or the combined inhibition of the major metabolic pathways of glutamine, has emerged as a promising novel strategy to overcome metabolic therapy resistance
The liver accumulates scar tissue, loses its ability to function properly, and may eventually develop cirrhosis
Hepatocellular carcinoma HCC stands as the most common primary liver cancer and is a leading cause of cancer-related deaths worldwide, with its incidence continuing to rise [97]
10.1016/S0024-3205(00)00722-0
Hepatocyte growth factor/scatter factor-induced activation of MEK and PI3K signal pathways contributes to expression of proangiogenic cytokines interleukin-8 and vascular endothelial growth factor in head and neck squamous cell carcinoma
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