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They do not just block symptoms

Side Effects & Risks Common : Mild injection site irritation, transient nausea, headaches (rare, 100 PubMed studies (e.g., PMID 30915550: tendon healing

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The 177191 fragment was identified as the lipolytic active site, and a tyrosine residue was added at the N-terminus to enhance stability

this allows for radical activation of an otherwise inert CH bond in the ribose ring of the substrate bound to R1

This progression is what leads to the severe Lower Urinary Tract Symptoms (LUTS) and eventual retention issues