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Patients benefit from understanding the neurobiological basis of their motivation difficulties, as this knowledge reduces self-blame and increases treatment adherence
Reactive oxygen species (ROS), particularly hydrogen peroxide (H 2 O 2 ), strongly potentiate NF-B activation by stimulating redox-sensitive upstream kinases such as TAK1 and inhibiting phosphatases including PP2A, thereby accelerating IB degradation and nuclear signaling (Vainshtein and Sandri, 2020) (Zhang H
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Conservative Approach: Pregnancy: Doctor consultation absolutely necessary Breastfeeding: Limited research available Trying to conceive: Better to avoid until conception Conflicting Views: experts generally safe recommend complete avoidance FDA has no official guidelines 2
