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While intermediate metabolites associated with TCA cycle (Tricarboxylic Acid Cycle) such as fumarate, succinate, and malate were not significantly different between the groups, we suggest a decrease in mitochondrial activity may result in lower ATP generation as reported in other inflammatory conditions (65, 66)

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6.3 Modulation of oral and gut microbiota composition by diet The Mediterranean diet, rich in dietary fiber and polyphenols, provides key substrates for microbial fermentation and ecological balance

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Kim, Y.H

It is likely that high concentrations in crystallization push the equilibrium towards peptide-WD40 binding, as suggested previously 61