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The 2025 systematic review noted that despite increasing clinical use, this level of evidence does not yet exist

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It was first described and also named in 1921 (Hopkins) and in 1935 it could be synthesized and its structure was definitively established

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Such symptoms have resulted from the over-stimulation of the thyroid due to the induction of hyperthyroidism through exogenous thyroid hormones and in turn cause excessive secretion of thyroid hormones, which disturb the feedback loop of the hypothalamic-pituitary-thyroid axis (Bao et al