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Peptides often work by saturating receptors or triggering a systemic response, which is less dependent on the user's mass

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MS (ES+) m/z 544.1.1H NMR (300 MHz, MeOD): H (ppm) 1.39 (s, 9H, BOC), 1.481.49 (m, 27H, 3xOtBu), 2.05 (t, 2H), 2.18 (m, 2H), 2.29 (m, 2H), 2.35 (t, 2H), 3.90 (dd, 1H,CH, 3J = 9.4 Hz, 3J = 4.27 Hz), 4.27 (dd, 1H,CH, 3J = 8.95 Hz, 3J = 5.29 Hz).13C NMR (75 MHz, MeOD):C (ppm) 26.48, 26.6, 27.1, 28.7, 30.43, 32.8, 52.97, 54.22, 79.87, 82.11, 156.58, 171.75, 173.1, 174.13

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In summary, although the two neurons did not die of GPX4 reduction, the study focused on only one point of GPX4 and did not delve into other regulators, indicating that there are other pathways affecting the activity of POMC neurons under obesity conditions (129)

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