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For example, in IL-1-deficient mice, neither local tumors nor lung metastases developed after localized or intravenous inoculation with melanoma cell lines, which suggests that IL-1-induced inflammation participates in the invasiveness of already existing tumor cells [65]

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These are impressive figures considering that HTPs not too many years ago were regarded as little more than gimmicks, which according to some industry observers were unlikely to prevail against traditional tobacco products in the long term

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