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Sermorelin was first developed in the 1970's

Melasma appears as flat, dark patches, brown to greyish-brown, most commonly on the cheeks, forehead, bridge of the nose, upper lip, and chin

The conservative approach suits several situations

When the control group is asymptomatic, as in this study, high values for true negatives and low values for false positives are usually easily achieved, resulting in a high specificity value

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They regulate critical biological functions like healing, inflammation, immune response, and tissue regeneration