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Since no appropriate PR3-AAV model exists, clinical studies with adjunctive DPP1 inhibitor administration in patients with PR3-AAV may provide the best approach to test this hypothesis
Additionally, both low and high doses of taurine (100 and 400 mg/kg via oral gavage) over nine weeks increased GSH in brain homogenates of mice exposed to D-galactose (22) and improved cognitive deficits in the aging model used in that study
