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Clinical Evidence on Long-Term Glutathione Depletion and Health Outcomes Several in vitro and animal studies demonstrate acetaminophen-induced glutathione depletion impairs antioxidant defense and cellular repair

PLoS ONE 8, e56711, 10.1371/journal.pone.0056711 (2013)

doi: 10.1067/mlc.2002.129504

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In line with these findings, Tao and colleagues reported impaired cancer cell motility, decreased lymph node metastasis and prolonged overall survival following Met knockdown in an in vivo model of HNSCC (35)