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The acceleration of cell turnover caused by tretinoin pushes impurities to the surface more rapidly, resulting in a temporary increase in acne, whiteheads, and blackheads lasting anywhere from 4-6 weeks

doi: 10.3389/fphar.2025.1602976 Received 30 March 2025 Revised 13 November 2025 Accepted 14 November 2025 Published 19 December 2025 Volume 16 - 2025 Edited by Bernd Rosenkranz, Fundisa African Academy of Medicines Development, South Africa Reviewed by Kacper Nijakowski, Poznan University of Medical Sciences, Poland Miriam Njoki Karinja, Science for Africa Foundation, Kenya Updates Copyright 2025 Mazur, Ndokaj, Salerno, Vallone, Ardan, Bietolini, Carrouel, Wilk, Sarig, Ottolenghi and Bourgeois

Gastrointestinal effects Nausea is the most commonly reported side effect with both compounds individually

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Swanson L-Glutathione + CoQ10 combines two powerful antioxidant nutrients that help support cellular health, antioxidant protection, and overall wellness