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We were exploring ways of developing peptides that bind selectively, and we were very successful at that, but then we confronted the problem that our short, 23-residue peptides are not promising therapeutic candidates primarily because they cannot get into cells, Keating says

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The dorsal root ganglia (DRG) and spinal cords (SC) were collected, and then, the number of cytokine-positive cells was determined via immunostaining

Notably, the combination of AOD9604 and HA appeared to offer greater benefits than either agent alone, suggesting a synergistic effect in promoting cartilage protection and repair [1]

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