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Under chronic conditions, the neuroinflammatory response fosters a toxic microenvironment that exacerbates syn pathology

Rather than being investigated within a single biological pathway, it has featured in laboratory studies examining molecular signalling, extracellular matrix biology and the complex interactions that influence normal tissue organisation

As dexamethasone, a potent anti-inflammatory glucocorticoid, prevents the neurodegenerative effect of LPS, it can be argued that inflammation is the primary cause for neuronal death [296]

Localization of the glucocorticoid receptor in rat brain mitochondria

doi: 10.3389/fendo.2019.00510 130 LeinonenHMKansanenEPlnenPHeinniemiMLevonenAL

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