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In the Phase 2 clinical trial (NEJM, 2023), retatrutide was administered subcutaneously at doses ranging from approximately 0.5 mg to 12 mg per week, with dose escalation under close medical supervision

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Withdrawal rates due to adverse effects serve as a practical measure of real-world tolerability, as they reflect whether side effects are bothersome enough to outweigh potential benefits

With each step-up, the body may need a few days to adapt

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