Prescription and administration: Once B12 deficiency is confirmed, GPs prescribe hydroxocobalamin injections according to standardised protocols: Standard loading regimen: 1mg intramuscularly three times weekly for two weeks Neurological involvement: 1mg intramuscularly on alternate days until no further improvement Maintenance therapy: 1mg every three months for life in pernicious anaemia or malabsorption conditions (or every two months if there was neurological involvement) Injections are typically administered by practice nurses at GP surgeries
Higher doses may increase GI side effects (nausea, reduced appetite)
Tripeptide-1 Tripeptide-1 can effectively promote the production of type I and type III collagen, elastin and structural glycoproteins such as laminin and fibronectin
Common approaches include 4 weeks on followed by 2 weeks off, 6 weeks on followed by 4 weeks off, or running continuously until the injury resolves and then stopping
doi:10.1016/S0140-6736(23)01163-7 Davies MJ, Bajaj HS, Broholm C, et al
Research has found a link between low vitamin B12 levels and depression, and there are several mechanisms by which this vitamin may influence mental well-being: It is involved in the production of "feel-good" hormones such as serotonin and dopamine, which greatly influence mood
