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When oxidative stress increases, Nrf2 moves to the nucleus enhancing the expression of antioxidant genes, such as NAD(P)H: quinone oxidoreductase 1 (NQO1), heme oxygenase-1 (HO-1), GCL, microsomal epoxide hydrolase, GST, and sulfiredoxin 1 [217]

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doi: 10.1016/s0015-0282(02)04948-8

NOS is a heme-containing enzyme with oxidative and reductase spheres linked via calmodulin

Trends Biochem Sci 13:185188

Information on ethnicity or smoking status of subjects enrolled in the trial is not available