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Several compounds have been shown to interfere with melanosome transport or to activate autophagy in cultured melanocytes and pigmented skin models (Supplementary information 4.1)

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Probably the most important example for such an alternative concept is the mitochondrial cascade hypothesis put forward already years ago by Swerdlow and coworkers, assuming mitochondrial dysfunction with enhanced oxidative stress and elevated free radical (ROS) production as the major pathomechanism of AD which slowly develops by aging and finally leads to the clinical disease

Winder, K