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Endalifer ML, Diress G (2020) Epidemiology, Predisposing Factors, Biomarkers, and Prevention Mechanism of Obesity: A Systematic Review

It is worth noting that the sulfate moiety of IS can interact with a neighboring positively charged functional group in the ligand-binding pocket of the AhR, and plays an essential role in the toxic activity associated with IS [37]

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In addition, ensuring that test conditions (such as the timing of supplementation, exercise type, and environmental factors) are standardized will help improve the reliability of the results and allow for better comparisons across studies