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Building on previous discoveries, recent research has revealed that exogenous factorsparticularly cigarette smoke exposurecan fundamentally remodel this dynamically balanced architecture via nicotine-mediated epigenetic pathways (Table 3)

2 As discussed in the Introduction, these two epidemics tobacco and TB are on a collision course

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Fine particles can travel deep into the lungs and contribute to inflammation, oxidative stress, and cellular damage

Smoking has the dubious distinction of affecting all the systems from head to foot