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Some PK studies report an increased theoretical risk of toxicity with advancing age [62,63,64,65,66,67] due to prolongation of t 1/2 [62, 63], reduced paracetamol clearance [64, 67], increased paracetamol oxidation caused by a reduction in glucuronidation and sulphation capacity [65] or a reduction in liver volume [66]
Treatment with recombinant human -Gal A (rh-GLA) A previous in vitro study on Fabry disease using mouse aortic endothelial cells from -Gal A-deficient mice showed that rh-GLA treatment for 48 hr reduced Gb3 at a dose from 0.160 g/ml 20
Rev Fac Cien Med Univ Nac Cordoba 45, 2830
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