Most cases are transient self-limiting (physiological neonatal jaundice) occurring in the first week of life, but some can be a sign of pathological disorders, particularly liver diseases
This is why people taking large oral doses of Vitamin C often report gastric distress
455 Conversely, the effect of bosentan remains controversial, warranting more comprehensive investigations in large population cohorts
However, conventional medicine considers the majority of cases idiopathic, meaning the cause is unknown (Marangella 2008
Pharmacol Rep 65(4):884890 Chang JT, Liang YJ, Hsu CY, Chen CY, Chen PJ, Yang YF et al (2017) Glucagon-like peptide receptor agonists attenuate advanced glycation end products-induced inflammation in rat mesangial cells
They came in louder over the last twelve months, and louder still in the last few weeks