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Species interaction at the cellular level, dispersion or intercellular lipids extraction, increased fluidity of stratum corneum lipid bilayers, higher drug thermodynamic activity, and greater SC hydration are all mechanisms that support drug administration using chemical enhancers [283]

doi: 10.1016/j.bbamcr.2019.04.006 157 TangXLiXZhangDHanW

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Factors that can increase the risk of B12 deficiency include being over the age of 75, digestive absorption issues, autoimmune conditions, and certain diets like vegetarianism and veganism