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Ethacrynic acid is a potent inhibitor of NF-kB-signaling pathway, and also modulates leukotriene formation

2023;15:evad172

A hypothesized mechanism is attributed to L-cells that co-produce GLP-1 and GLP-2 at the same time, which regenerates intestinal epithelium, mediates peptide YY production, and subsequently, through appetite suppression, prolongs satiety through GLP-1 receptors and thus manages weight control [33, 47]

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(ii) cytokine storm-induced immune-metabolic reprogramming, which could elevate kynurenine:tryptophan ratio and trigger chronic depression syndrome 729

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