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A protease inhibitor cocktail (Sigma-Aldrich, MO, USA) was added at a concentration of 10 L/mL before homogenization

Viral nsp12 could alter AA metabolism (especially of the branchedchain amino acids , BCAA), while nsp12, nsp7 , and nsp8 interactions with electron transport chain (ETC) and ribosomal proteins could potentially dysregulate mitochondrial respiration 39

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Therefore, we need to identify commonalities among different organs to truly reveal the effects of FOXO4-DRI in anti-aging

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