Compared with vehicle control, KL1 treatment led to upregulation of 24 host genes and downregulation of 90 host genes (Extended Data Fig
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Furthermore, the absence of strong data from clinical trials on novel therapeutic targets, such as inflammasome inhibitors or microbiome-modulating agents, limits the strength of conclusions regarding their efficacy and safety in humans
One of the striking features of GST is that each subunit has two ligand-binding sites - G site and H site (Figure 3), which together constitute the catalytic active site [62, 77]
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