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Esculetin as a coumarin compound in various plants exhibited strong anti-inflammatory effect, reduced the levels of IL-1, IL-6, and TNF- in serum and hippocampus, and down-regulated the hippocampal expression of iNOS and COX-2 in LPS-depressed mice (97)

Conclusion Taken together, migraine patients are more prone to have insufficient dietary intakes due to their nausea and vomiting

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