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The chondral defect (4 mm in diameter) was created in the trochlear groove of the distal femur according to a previously described method [24]

Patches of edema appear after initial symptoms clear and are usually found on the abdomen

Experientia supplementum

Images were analyzed using the Adiposoft plug-in software in ImageJ (NIH).[22] Briefly, images were converted to 8-bit images and scald to 0.366 microns per pixel (corresponding to 20 magnification on the Leica microscope)

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