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Toxic mechanism Nicotine binds stereoselectively to nicotinic acetylcholine receptors (nAchRs), which are pentameric ligand-gated ion channels (LGICs), localised in the peripheral and central nervous system, autonomic ganglia, sympathetic and parasympathetic nervous system, and skeletal neuromuscular junctions 10 , 23

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Unfortunately, their mismanagement led to a decline marked by misguided strategies, which culminated in Lang's departure from the brand in 2005, bereft of creative control