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The compounded semaglutide with B12 injection makes it convenient to take both drugs together and ensures higher bioavailability than oral B12 supplements, avoiding gastrointestinal absorption issues

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Consequently, a deficiency in vitamin B12 can lead to anemia and neurological issues such as muscle weakness, cognitive decline, depression, fatigue, neuropathy, and stroke

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However, a study found that taking 1,000 mcg of B12 by mouth or injecting the vitamin achieved similar results in treating the deficiencies