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This variant is classified within the One category (~1 mg tar) , achieved through intensive filter ventilation and paper porosity adjustments , rather than changes in the tobacco composition

Pulm Pharmacol Ther 2019;56:116-25

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When exploring changes of model fit in further models (Table S3, additional file 1), we found considerable improvement of the model fit only by additional adjustment for the ratio of cotinine/3OH-cotinine (adjusted R 2 men 0.40, women 0.41)