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Functional studies in zebrafish have provided in vivo evidence that disruption of Pgrmc1 (progesterone receptor membrane component 1)a membrane-associated protein that physically interacts with CYP51A1leads to cataract formation, likely due to impaired CYP51A1 activity and dysregulated cholesterol metabolism [48]

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Transport There are few measurements of overall transport rates of the metabolites between the compartments of the model