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JAMA 309 , 24732479 (2013)
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The nine tissue systems now documented in the preclinical literature were not predicted by computational models or receptor-binding assays at the outset they were identified sequentially as researchers in different laboratories independently tested the compound against different experimental injury models and consistently found meaningful effects
These were in the cerebellum (ibuprofen [238], paracetamol [239]), the cerebral cortex (diclofenac [240,241], celecoxib [201]), the frontoparietal cortex (concussive brain trauma) [231], the hippocampus and the cerebral cortex (insulin) [242], and the parietal neocortex and the hippocampus (cuprizone [232])
