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3.6.3.2 Microbial metabolites A substantial body of research highlights the role of gut microbiota and their metabolites, particularly SCFAs, in regulating metabolic, endocrine, and immune functions, with emerging evidence pointing to their involvement in neuro-immunoendocrine pathways through the MGBA (Silva et al., 2020)

doi: 10.1007/s12975-024-01258-5, 75 LinnerbauerM.BeyerT.NirschlL.FarrenkopfD.LleinL.VandreyO.et al

Effect of Tomato ( Solanum lycopersicum ) Extract in Patients with Primary Insomnia: A Double-blind Randomized Study

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These mitochondrial impairments not only compromise energy production but also act as pro-inflammatory stimuli, promoting chronic neuroinflammation through dysregulated mitochondrial signaling and innate immune response