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GSSG generated in these processes can be either recycled to GSH by a NADPH-dependent reaction, catalyzed by GR 3 , or pumped out of the cell by ATP-dependent processes, with multidrug resistance-associated protein-1 (MRP-1) being the major pathway for GSSG efflux 33

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These will increase glutathione levels in the body which canlikewise renderthe treatments ineffective

Furthermore, there is a clear ascending trend in the number of clinical trials in cancer nanomedicine [445]