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Studies have shown that tamoxifen resistance is associated with IGFBP-1 accumulation and that the overexpression of IGFBP-1 promotes tamoxifen resistance in breast cancer cells by activating the ERK pathway, which can be reversed by knocking down IGFBP-1 (134)

After reconstitution, store the solution in the refrigerator at 2-8C and use it within 7-14 days to maintain its potency and effectiveness

Safety: This reclassification acknowledges the safety data presented in recent years and ensures that patients can access these tools through regulated, high-quality pharmaceutical channels rather than unregulated sources

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10.1097/00008390-200408000-00050 [DOI] [Google Scholar] Rayner, B