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To serve as mucoadhesive polymers, the polymers should possess some general physiochemical features such as predominantly anionic hydrophilicity with numerous hydrogen bond forming groups, suitable surface property for wetting mucus/mucosal tissue surfaces and sufficient flexibility to penetrate the mucus network

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Inhibitory drugs of cyclooxygenase reduce flushing by mediating the formation of prostaglandins [166,167,168], improving quality of life in the therapeutic supplementation of niacin [169]