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When GSH levels are chronically low, immune cells within the CNS shift to a damage-oriented phenotype

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Reactive oxygen species grow as a result of cancer cell proliferation, which may damage macromolecules and ultimately cause cell death

Malaria Infection Infections with malaria parasites may stimulate the immune system leading to ROS formation, which can attack the plasma membrane of the erythrocyte compromising its integrity [27]

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Namely, KEAP1 is a redox biosensor utilizing reactivity of sulfur atoms, switching on the NRF2-mediated transcriptional activation of cytoprotective genes in response to the redox disturbance