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Based on the available research, GHK-Cu appears to exhibit a favorable safety profile across a variety of subject populations

Pickart L, Thaler MM (1973)

In preclinical work, MOTS-c is described as interfering with the folate cycle, leading to a build-up of AICAR (an AMP analog) that switches on AMPK [1] [2]

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While direct mutagenic effects were not identified in safety studies, proliferative effects were, representing a plausible pathway for increased risk of PDAC