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Mechanistically, echinatin activates nuclear factor, erythroid-derived 2, like 2 (Nrf2)/glutamate-cysteine ligase catalytic subunit (GCLC)/glutamate-cysteine ligase, modifier subunit (GCLM) signaling axis, which maintains the GSH homeostasis and thereby inhibits ferroptosis

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Therefore, the iron-rich environment created by recurrent hemorrhage in endometriosis likely contributes directly to the induction of senescence in ectopic endometrial cells or surrounding peritoneal cells