This role is due to a metabolite of selenocysteine called seleno-cysteinyl (a molecular form of the cysteine moiety) that allows the full gene transcription of Se-GSH-Px (Johansson et al., 2005)
These came up short of expectations, but there were also winners -Bristol Myers Squibbs LAG3 (Opdualag) + CTL4 (Yerovy), both of which are expected to be multi-billion dollar drugs
For instance, a study in the Journal of Dermatological Treatment found that oral glutathione for skin may help lighten skin after a few weeks
Matrix stiffness induces epithelial-to-mesenchymal transition via Piezo1-regulated calcium flux in prostate cancer cells
Glutathione benefits are plenty and the number of available brands, products, and cosmetics containing it are seemingly endless
Increasing selenium levels may reduce the risk of developing neurodegenerative disease in populations with low selenium exposure