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Consistently, loss of WT1 activity in Wilms' tumour and related malignancies may result in transcriptional derepression of the IGF-1R gene (Gerald et al, 1995)

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"Synthesis and Biological Evaluation of Epidithio-, Epitetrathio-, and bis-(Methylthio)diketopiperazines: Synthetic Methodology, Enantioselective Total Synthesis of Epicoccin G, 8,8- epi - ent -Rostratin B, Gliotoxin, Gliotoxin G, Emethallicin E, and Haematocin and Discovery of New Antiviral and Antimalarial Agents"

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Although the concentrations of sugars, aldehydes, and oxidants in the experiments exceeded physiological levels, they were instrumental in simulating physiological processes occurring over weeks or even months in the human body within a relatively condensed timeframe