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Specifically, this included increased ( Egr, Nos, Srf, and Kras ) or decreased ( Egr, Vegfr, and Plc ) gene expression, while Akt1 gene expression remained unchanged (Vukojevic et al., 2018)
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267 Although these trials utilized combination therapy rather than sequential therapy, strategies combining senescence inducers (e.g., etoposide, olaparib, or paclitaxel) with senolytics (e.g., navitoclax) have demonstrated clinical benefits in studies
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