Small molecules such as RSL3 and erastin, which primarily target GPX4 and SLC7A11, respectively, demonstrate that impairment of cystine uptake or lipid peroxide detoxification is sufficient to directly trigger ferroptotic cell death
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Scientists are still exploring whether these biological actions are direct effects of the peptide or secondary effects of overall cellular signaling
PLoS ONE 8 , e63865 (2013)