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Dickkopf 1 (DKK1) regulates SHMT2 transcription through the AKT-Sp1 (Specificity Protein 1) signaling axis, modulates redox homeostasis and mitochondrial function, and exerts anti-apoptotic and proliferative effects on human PAECs (hPAECs), thus playing a positive role in vascular remodeling related to pulmonary hypertension (PH) [143]

2014 Oct;109(10):154761

Bishop JB, Phillips LG, Mustoe TA, VanderZee AJ, Wiersema L, Roach DE, et al

These reactions can escalate quickly

the calculated stability l n based on single phase exponential decay for Norleual was 4.6 min and for D-Nle-Tyr-Ile-NH-(CH 2 )5-CONH 2 stability t 1/2 was 79.97 min

doi: 10.1111/acel.12188