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Added to this are pronounced socioeconomic differences, which are reflected in the fact that socially more disadvantaged subgroups of the population are more likely to smoke and less likely to succeed in their attempts to quit smoking (7, 8)

Changes in the spontaneous tonic firing of VTA DA neurons, as a consequence of repetitive drug use, can indeed alter the subjective value assigned to available rewards 21 , as well as the motivational salience of the drug or of drug-predicting cues 24 , influencing decisions about which reward to pursue 25