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This imposes an enormous physical, psychological, and economic burden on affected patients, as a BC diagnosis necessitates a lifetime of surveillance to detect and treat tumors as they reemerge resulting in the highest lifetime per-patient treatment costs of any cancer type 5

The slides were imaged with a Confocal-A1 (Nikon, Tokyo, Japan) confocal microscope and analyzed by Image J software (NIH, MD, USA)

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