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Pathogen exposure may trigger trained immunity in sarcoidosis, peripheral blood mononuclear cells (PBMCs) from patients produce higher TNF and IL-6 levels upon bacterial or fungal stimulation than those from healthy controls and show abnormal expression of pathogen-sensing PRRs (44)

10.1007/s12274-019-2300-4 12 GoenkaS.SantV.SantS

Its defined structure and stability make it suitable for in-vitro and preclinical research models where reproducibility and consistency are essential

The slides were mounted with Fluoprep (BioMerieux), and immunofluorescence was viewed and analyzed using an Imager Z1 fluorescence microscope equipped with a Digital Camera (Zeiss, Jena, Germany) connected to an AxioVs40 software (Zeiss), and with an LMS800 confocal microscope piloted by a ZEN 2.3 software (Zeiss)

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Increased blood flow to damaged tissue means faster delivery of nutrients and oxygen, both of which are critical for repair