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The reaction solution gradually becomes black, stirred at room temperature for 3 h, the solvent is concentrated to 10 mL by distillation under reduced pressure

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-Secretase has been characterized as a membrane-bound aspartic protease termed beta-site APP-cleaving enzyme 1 (BACE1), while -secretase is a complex comprised of presenilin-1 or -2, nicastrin, anterior pharynx-defective 1 (Aph-1) and presenilin enhancer 2 (Pen-2

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These figures are provided for research reference only and do not constitute dosing recommendations