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The activity of GST and APX involve APX-GSH cycle, no significant different activity reveal that it may be not the main factor affecting GSH metabolism

This dietary intervention can impact metabolic flux in one-carbon metabolism, inhibit tumor growth, and sensitize tumors to chemotherapy and radiotherapy in certain human cancer cells in a tumor-cell autonomous manner 14

doi: 10.1056/NEJMoa1110404 79 DayA

doi:10.1161/ATVBAHA.107.152298 [PubMed][Crossref] 6

This metabolic disruption is majorly caused due to the higher inclusion of carbohydrates and fat in the diets, in the case of fish

Elevated levels (hyperhomocysteinemia) act like a "trigger," stimulating immune cells (monocytes) to release pro-inflammatory cytokines such as IL-8 and MCP-1